Prescriptions That Don’t Mix With CANNABIS

What MEDICATIONS Should You Avoid When Taking Medical Marijuana?

Cannabis is generally safe to use with most prescription medicines. However, it’s critical to talk to your doctor if you want to utilize cannabis while taking other medications. Physicians and pharmacists are not required by law to inquire about your medical card if you have one, although they will generally ask if you are currently ingesting tobacco, marijuana, or alcohol. They can’t provide information on potential drug interactions until you let them know, so although it may seem tedious to list every single prescription, medical, vitamin and herbal supplement you take, it’s important to take stock of this info regularly.

There has not been a single example of death caused by marijuana alone. You may consume too much marijuana and experience negative effects, although dispensaries are extremely careful in order to mitigate this risk. Toxicity symptoms like nausea, paranoia, anxiety, or brain fog tend to lessen without medical treatment. Taking dosages outside of recommendation limits might be so distressing that even a typical marijuana user understands his or her limit.


However, the study’s most concerning finding is that patients are afraid cannabis may make their prescription medications less effective. It might be a significant risk for people with cancer, diabetes, or cardiac problems. Cannabis may exacerbate your symptoms if you take psychotropic medicines to manage mild to severe depression or anxiety.

Patients may be unaware of HIGH-RISK medications

Cannabis and several medicines react in unpredictable ways. Cannabis can have the same or even greater therapeutic effects as some pharmaceuticals, and it might be able to interfere with the way those medications function in the body. In the medical field, a contraindication is anything (including a symptom or medical condition) that is a reason for a person to not receive a particular treatment or procedure because it may be harmful. It covers everything from routine medicines to after-care for operations or procedures.


Cannabis has contraindications in medicine, as it can lower the effectiveness of prescription medications or interfere with other treatment plans. Cannabis affects enzymes produced in the liver, for example. When this happens, medicines may not be absorbed effectively. Cannabis can slightly reduce antibiotic biosynthesis, making it harder for your body to effectively utilize a round of antibiotics prescribed by your family doctor. It may also cause adverse effects, such as nausea and abdominal discomfort, more commonly based on the other medications you take daily.

As always, be safe and fully disclose everything to your physician. This includes the name of the medicine, the rate of application, the dosage, and any relevant information on how it is taken. Is it more difficult for you to discuss medical cannabis with your family doctor? Look for a board-certified physician who specializes in cannabis recommendations, or approves of working in tandem with patients who are already part of the treatment plan. That expert can provide professional guidance on medical marijuana as well as speak with your family doctor on your behalf.

Medical cannabis, like any other medicine, is protected under the Health Insurance Portability and Accountability Act (HIPAA). It can’t be shared outside of the doctor/patient relationship or without your permission. You’ll need the continuing advice and recommendations of a doctor to ensure that medical cannabis does not interfere with your existing prescription medications. Safety first!

7 Prescriptions that don’t mix with medical marijuana

Few pharmaceuticals interact with medical marijuana. Many individuals, however, take the following seven medicines to cure diseases including seizures, respiratory illness, and several other conditions. Additionally, these medicines have been found to react badly with marijuana. This list is not exhaustive, so as always, you will still need to discuss any contraindications with your doctor.

1. Anti-Anxiety and Antidepressants Prescription Medications

Benzodiazepines are a type of prescription that is frequently given to people who suffer from anxiety, depression, or sleeplessness. Benzodiazepines, on the other hand, can cause memory loss and even blackouts. Cannabis might cause memory loss of the patient, which is strengthened by simultaneous use and results in a “mental fog” and temporary memory loss.

The following are some examples of typical pharmaceutical medications in this class:

  • Vortioxetine (Trintellix)
  • Citalopram (Celexa)
  • Sertraline (Zoloft)
  • Escitalopram (Lexapro)
  • Fluoxetine (Sarafem, Selfemra, Prozac)

There are many types of drugs that affect how your body works. Most antidepressants don’t work well together with other types of drugs. Then, it also includes medical cannabis.

They can be more anxious if they have moderate to severe Attention Deficit Hyperactivity Disorder (ADHD), Generalized Anxiety Disorder (GAD), or Post-Traumatic Stress Disorder (PTSD). Using cannabis can make you more paranoid and stressed, depending on the strain, THC content, and your method of ingestion.

People with medical cards don’t take antidepressants and anti-anxiety drugs together, so most doctors won’t prescribe them if they know the person has a medical card.

2. Clobazam

It is a type of medication that is prescribed to people who have seizures. It is a benzodiazepine. There is a new kind of medication that comes from cannabis and it is called Epidolex. This medication can help people who have seizures, but it can also stop other medications from working properly. Clobazam is significantly less effective when taken with food. Because Clobazam becomes less effective when taken with food, the drug’s concentration in blood plasma is decreased as a result. This can lead to an enhanced degree of drowsiness or sedation.

Cannabis, like cannabidiol (CBD), can be used to treat patients. However, physicians will generally reduce the dosage of Clobazam therapies to counteract the drowsy effects because both cannabinoids and clobazam have sedative properties.

3. Subutex and Suboxone

Suboxone, Subutex (as well as Buprenorphine), and Suboxone are all opioid addiction treatment medications that can be given to persons recovering from substance dependence on opioids like Fentanyl, heroin, or Oxycodone. When part of step-down addiction therapy, the medicines are utilized to make withdrawal symptoms easier to handle.

Using cannabis with Subutex, Suboxone, or other Buprenorphine-based medications raises several safety concerns. When cannabis is combined with this class of medicines, it may cause severe mood swings. Respiratory depression (problems breathing) can be deadly if cannabis is taken along with these drugs.

Consequently, because Buprenorphine is incompatible with cannabis for a second reason, it is also prohibited. Cannabis and high-grade CBD can decrease the effectiveness of Subutex and Suboxone. This finding implies that people may not get sufficient pain relief or relapse into opioid addiction after discontinuing these medicines.

4. Seroquel

In order to treat the symptoms of bipolar disorder, you can use Seroquel. The drug (Quetiapine) can make some of the side effects worse, like confusion, dizziness, concentration problems, and drowsiness.

Seroquel can also make it hard for people to move and work together if they take it with marijuana. When you’re taking prescription drugs, don’t avoid taking them unless you talk to a doctor. Reducing or stopping a patient’s daily dose of medicine can be dangerous for their health and safety.

5. Theophylline

Theophylline is a medication frequently used to treat chronic respiratory disorders such as asthma, emphysema, and bronchitis. Because smokable marijuana may dissolve or metabolize the drug quickly, it may make it less effective. Other types of marijuana (such as tincture drops or edibles) might not have the same negative effect.


6. Valproate

Valproate is a prescription medicine that is used to treat epileptic fits. This drug is usually given to people who suffer from bipolar illness or severe migraine headaches. The combination of Epidiolex (CBD) and Valproate has been found to work three times better in clinical trials, increasing the risk of liver damage.

7. Warfarin

When individuals are at a higher-than-normal danger of forming blood clots, warfarin is given. DVT (Deep vein thrombosis) is the formation of one or more blood clots in the thigh, leg, or pelvic region.

The inhibitory effect of THC and CBD on the metabolic activity of CYP2C9, an enzyme that can raise warfarin levels, explains why patients who use marijuana may have increased bleeding risk. That indicates a higher chance of bleeding from an INR ratio to dangerously high levels, putting the patient in danger of life-threatening blood loss.

What if your doctor doesn’t know that you’re taking medical marijuana?

Some doctors are in favor of alternative therapies and therapeutic approaches that work for their patients. Other doctors may have their own reasons for not liking cannabis. It might not be something that they want to tell their patients about, or discuss at any point in time. Doctors can be afraid of being sued by their place of work for implying alternative treatment plans such as medical marijuana, as well.

Some medical professionals will be wary of cannabis as long as it is classified as a Schedule 1 drug under the Controlled Substances Act. If your doctor is against medical cannabis, you may not even have the opportunity to breach the subject with them, so finding a care provider who aligns with your needs is that much more important.

As a patient who wants to try new things like CBD or medical marijuana, you may not want to fight for your right to try them. As a result, you may not even have told your doctor that you also have a health card. Some people, understandably, prefer to keep their medical marijuana use a secret. However, not telling anyone about your medical marijuana use could put your health at risk. You must be a registered patient to use medical marijuana, and your care team should be aware of any and all changes in your treatment as it pertains to your current health conditions.


People who use cannabis and prescription drugs don’t always get along. Your doctor needs to know about anything you are taking, and it’s recommended to update them accordingly whenever anything changes. CBD supplements and medical marijuana are also included in this. You may even be taking vitamins and other nutritional products every day which you wouldn’t generally consider divulging with your care team, but even common vitamins and herbs can be contraindications to common prescription medications or medical marijuana.

The best course of action is for you to be completely candid with your physician. They may disagree with it personally, but the info will assist them in making more informed prescription decisions about your health. It doesn’t matter if they don’t like the idea of you using medical marijuana. You can always find another doctor who is okay with that, and will benefit more from making the switch.

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Ohio Green Team – Medical Marijuana Doctors & Recommendations
1733 W Lane Ave Suite 6, Columbus, OH 43221

Ohio Green Team – Medical Marijuana Doctors & Recommendations

1733 W Lane Ave Suite 6, Columbus, OH 43221

Call today! 614-639-0257

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